研究室発足以後の主要発表原著論文
  (最近の論文については、 PubMedにリンクしています。)

  1. Seong KH, Ly NH, Katou Y, Yokota N, Nakato R, Murakami S, Hirayama A, Fukuda S, Kang S, Soga T, Shirahige K & Ishii S: Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells. Commun. Biol. 3, 208 (2020).

  2. Yoshida K, Maekawa T, Ly NH, Fujita SI, Muratani M, Ando M, Katou Y, Araki H, Miura F, Shirahige K, Okada M, Ito T, Chatton B & Ishii S: ATF7-dependent epigenetic changes are required for the intergenerational effect of a paternal low-protein diet. Mol. Cell 78, 445-458 (2020).

  3. Liu Y, Maekawa T, Yoshida K, Muratani M, Chatton B & Ishii S: The transcription factor ATF7 controls adipocyte differentiation and thermogenic gene programming. iScience 13, 98-112 (2019).

  4. Liu B, Maekawa T, Yoshida K, Ly NH, Inoue K, Hasegawa A, Chatton B, Ogura A & Ishii S: Telomere shortening by transgenerational transmission of TNF-α-induced TERRA via ATF7. Nucleic Acids Res. 47, 283-298 (2019).

  5. Yoshida K, Muratani M, Araki H, Miura F, Suzuki T, Dohmae N, Katou Y, Shirahige K, Ito T & Ishii S: Mapping of histone-binding sites in histone replacement-completed spermatozoa. Nat. Commun. 9, 3885 (2018).

  6. Maekawa T, Liu B, Nakai D, Yoshida K, Nakamura K, Takubo K, Ysukawa M, Chatton B, Koike M, Ishikawa F, Masutomi K & Ishii S: ATF7 mediates TNF-α-induced telomere shortening. Nucleic Acids Res. 46, 4487-4504 (2018).

  7. Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Chatton B, Inoue K, Uchiyama T, Ishibashi K, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M & Ishii S: The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory. Nat. Immunol. 16, 1034-1043 (2015).

  8. Shinagawa T, Huynh ML, Takagi T, Tsukamoto D, Tomaru C, Kwak HG, Dohmae N, Noguchi J & Ishii S: Disruption of Th2a and Th2b genes causes defects in spermatogenesis. Development 142, 1287-1292 (2015).

  9. Shinagawa T, Takagi T, Tsukamoto D, Tomaru C, Huynh LM, Sivaraman P, Kumarevel T, Inoue K, Nakato R, Katou Y, Sado T, Takahashi S, Ogura A, Shirahige K & Ishii S: Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells. Cell Stem Cell 14, 217-227 (2014).

  10. Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates TNF-α-induced apoptosis. Mol. Cell. Biol. 33, 4971-4984 (2013).

  11. target="_blank"Seong KH, Li D, Shimizu H, Nakamura R & Ishii S: Inheritance of stress-induced, ATF-2-dependent epigenetic change. Cell 145, 1049-1061 (2011).
  12. Staton TL, Lazarevic V, Jones DC, Lanser AJ, Takagi T, Ishii S & Glimcher LH: Dampening of death pathways by Schnurri-2 is essential for T cell development. Nature 472, 105-109 (2011).
  13. Jones DC, Schweitzer MN, Wein M, Sigrist K, Takagi T, Ishii S & Glimcher LH: Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3. Proc. Natl. Acad. Sci. USA. 107, 8254-8258 (2010).

  14. Maekawa T*, Kim S*, Nakai D, Makino C, Takagi T, Ogura H, Yamada K, Chatton B & Ishii S (*equally contributed): Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene. EMBO J. 29, 196-208 (2010).
  15. Maekawa T, Jin W & Ishii S: The role of ATF-2 family transcription factors in adipocyte differentiation: anti-obesity effects of p38 inhibitors. Mol. Cell. Biol. 30, 613-625 (2010).
  16. Yamauchi T, Ishidao T, Nomura T, Shinagawa T, Tanaka Y, Yonemura S & Ishii S: A B-Myb complex containing clathrin and filamin is required for mitotic spindle function. EMBO J. 27, 1852-1862 (2008).
  17. Shimizu H, Shimoda M, Yamaguchi T, Seong KH & Ishii S: Drosophila ATF-2 regulates sleep and locomotor activity in pacemaker neurons. Mol. Cell. Biol. 28, 6278-6289 (2008).
  18. Kanei-Ishii C, Nomura T, Takagi T, Watanabe N, Nakayama KI & Ishii S: Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation. J. Biol. Chem. 283, 30540-30548 (2008).
  19. Maekawa T, Shinagawa T, Sano Y, Sakuma T, Nomura S, Nagasaki K, Miki Y, Saito-Ohara F, Inazawa J, Kohno T, Yokota J & Ishii S: Reduced levels of ATF-2 predispose mice to mammary tumors. Mol. Cell. Biol 27, 1730-1744 (2007).
  20. Okamura T, Shimizu H, Nagao T, Ueda R & Ishii S: ATF-2 regulates fat metabolism in Drosophila. Mol. Biol. Cell 18, 1519-1529 (2007).
  21. Kajino T, Omori E, Ishii S, Matsumoto K & Ninomiya-Tsuji J : TAK1 MAPKKK mediates TGF-β signaling by targeting SnoN oncoprotein for degradation. J. Biol. Chem 282, 9475-9481 (2007).
  22. Saita Y, Takagi T, Kitahara K, Usui M, Ezura Y, Nakashima K, Kurosawa H, Ishii S & Noda M: Lack of Schnurri-2 expression associates with reduced bone remodeling and osteopenia. J. Biol. Chem 282, 12907-12915 (2007) .
  23. Zhou H, Kim S, Ishii S & Boyer TG: Mediator modulates Gli3-dependent Sonic hedgehog signaling. Mol. Cell. Biol 26, 8667-8682 (2006).
  24. Jin W, Takagi T, Kanesashi S, Kurahashi T, Nomura T, Harada J & Ishii S: Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins. Dev. Cell 10, 461-471 (2006). (Selected as a featured article)
  25. Morita Y, Kanei-Ishii C, Nomura T & Ishii S: TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation. Mol. Biol. Cell 16, 5433-5444 (2005).
  26. Kurahashi T, Nomura T, Kanei-Ishii C, Shinkai Y & Ishii S: The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. Mol. Biol. Cell 16, 4705-4713 (2005).
  27. Sano Y, Akimaru H, Okamura T, Nagao T, Okada M & Ishii S: Drosophila activating transcription factor-2 is involved in stress response via activation by p38, but not c-Jun NH(2)-terminal kinase. Mol. Biol. Cell 16, 2934-2946 (2005).
  28. Kimura MY, Hosokawa H, Yamashita M, Hasegawa A, Iwamura C, Watarai H, Taniguchi M, Takagi T, Ishii S & Nakayama T: Regulation of T helper type 2 cell differentiation by murine Schnurri-2. J. Exp. Med. 201, 397-408 (2005).
  29. Tanikawa J, Nomura T, Macmillan EM, Shinagawa T, Jin W, Kokura K, Baba D, Shirakawa M, Gonda TJ & Ishii S: p53 suppresses c-Myb-induced trans-activation and transformation by recruiting the corepressor mSin3A. J. Biol. Chem. 279, 55393-55400 (2004).
  30. Kanei-Ishii C, Nomura T, Tanikawa J, Ichikawa-Iwata E & Ishii S: Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation. J. Biol. Chem. 279, 44582-44589 (2004).
  31. Kanei-Ishii C, Ninomiya-Tsuji J, Tanikawa J, Nomura T, Ishitani T, Kishida S, Kokura K, Kurahashi T, Ichikawa-Iwata E, Kim Y, Matsumoto K & Ishii S: Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 18, 816-829 (2004).
  32. Nomura T, Tanikawa J, Akimaru H, Kanei-Ishii C, Ichikawa-Iwata E, Khan MM, Ito H & Ishii S: Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1β and Ski. J. Biol. Chem. 279, 16715-16726 (2004).
  33. Alarcon JM, Malleret G, Touzani K, Vronskaya S, Ishii S, Kandel ER & Barco A.: Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice; a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron 42, 947-959 (2004). (Cover)
  34. Khan MM, Nomura T, Chiba T, Tanaka K, Yoshida H, Mori K & Ishii S: The fusion oncoprotein PML-RARαinduces endoplasmic reticulum-associated degradation of N-CoR and ER stress. J. Biol. Chem. 279, 11814-11824 (2004).
  35. Dai P*, Akimaru H* & Ishii S: (*equally contributed): A Hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of Ci. Dev. Cell 4, 917-928 (2003). (Selected as a featured article)
  36. Shinagawa T & Ishii S: Generation of Ski-knock down mice by expressing a long double-strand RNA from an RNA polynerase II promoter. Genes Dev. 17, 1340-1345 (2003).
  37. Harada J, Kanei-Ishii C, Nomura T, Khan MM, Kim Y & Ishii S: Requirement of the co-repressor HIPK2 for Ski-mediated inhibition of BMP-induced transcriptional activation. J. Biol. Chem. 278, 38998-9005 (2003).
  38. Kokura K, Nomura T, Khan MM, Kim H & Ishii S: The Ski-binding protein C184M negatively regulate TGF-βsignaling by sequestering the Smad proteins to cytoplasm. J. Biol. Chem. 278, 20133-20139 (2003).
  39. Chen D, Xu W, Bales E, Colmenares C, Conacci-Sorrell M, Ishii S, Stavnezer E, Campisi J, Fisher DE, Ben-Ze'ev A & Medrano EE: SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res. 63, 6626-6634 (2003).
  40. Dai P*, Shinagawa T*, Nomura T, Harada J, Kaul SC, Wadhwa R, Akimaru H, Sasaki H, Colmenares C & Ishii S (*equally contributed): Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev. 16, 2843-2848 (2002).
  41. Okada M*, Akimaru H*, Hou D-X, Takahashi T & Ishii S (* equally contributed): Myb controls G2/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc. EMBO J. 21,675-684 (2002).
  42. Tahirov TH, Sato K, Ichikawa-Iwata E, Sasaki M, Inoue-Bungo T, Shiina M, Kimura K, Takata S, Fujikawa A, Morii H, Kumasaka T, Yamamoto M, Ishii S & Ogata K: Mechanism of c-Myb-C/EBPβcooperation from separated sites on a promoter. Cell 108, 57-70 (2002). (Cover)
  43. Takagi T, Harada J & Ishii S: Murine Schnurri-2 is required for positive selection of thymocytes. Nature Immunol. 2, 1048-1053 (2001).(described in News & Views)
  44. Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP & Ishii S: Role of PML and PML-RARα in Mad-mediated transcriptional repression. Mol. Cell 7, 1233-1243 (2001). (Cover)
  45. Tahirov TH, Inoue T, Sasaki M, Kimura K, Morii H, Fujikawa A, Shiina M, Sato K, Kumasaka T, Yamamoto M, Ishii S & Ogata K: Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFβ. Cell 104, 755-767 (2001).
  46. Harbers M, Nomura T, Ohno S & Ishii S: Intracellular localization of the Ret finger protein depends on a functional nuclear export signal and protein kinase C activation. J. Biol. Chem. 276, 48596-48607 (2001).
  47. Khan MM, Nomura T, Kim H, Kaul CS, Wadhwa R, Zhong S, Pandolfi PP & Ishii S: PML-RARα alleviates the transcriptinal repression mediated by tumor suppressor Rb. J. Biol. Chem. 276, 43491-43494 (2001).
  48. Kokura K, Kaul SC, Wadhwa R, Nomura T, Khan MM, Shinagawa T, Yasukawa T, Colmenares C & Ishii S: The Ski protein family is reqired for MeCP2-mediated transcriptional repression. J. Biol. Chem. 276, 34115-34121 (2001).
  49. Sano Y & Ishii S: Increased affinity of c-Myb for CBP after CBP-induced acetylation. J. Biol. Chem. 276, 3674-3682 (2001).
  50. Monzen K, Hiroi Y, Kudoh S, Akazawa H, Oka T, Takimoto E, Hayashi D, Hosoda T, Kawabata M, Miyazono K, Ishii S, Yazaki Y, Nagai R & Komuro I: Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation. J. Cell Biol. 153, 687-698 (2001).
  51. Shinagawa T, Dong HD, Xu M, Maekawa T & Ishii S: The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice. EMBO J. 19, 2280-2291 (2000).
  52. Tanikawa J, Ichikawa-Iwata E, Kanei-Ishii C, Nakai A, Matsuzawa S, Reed JC & Ishii S: p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3. J. Biol. Chem. 275, 15578-15585 (2000).
  53. Nomura T, Khan MM, Kaul SC, Dong HD, Wadhwa R, Colmenare C, Khono I & Ishii S: Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes Dev. 13, 412-423 (1999).
  54. Tanaka Y, Patestos NP, Maekawa T & Ishii S: B-myb is required for inner cell mass formation at an early stage of development. J. Biol. Chem. 274, 28067-28070 (1999).
  55. Maekawa T, Bernier F, Sato M, Nomura S, Singh M, Inoue Y, Tokunaga T, Imai H, Yokoyama M, Reimold A, Glimcher LH & Ishii S: Mouse ATF-2 null mutants display features of severe type of meconium aspiration syndrome. J. Biol. Chem. 274,17813-17819 (1999).
  56. Sano Y, Harada J, Tashiro S, Gotoh-Mandeville R, Maekawa T & Ishii S: ATF-2 is a common nuclear target of Smad and TAK1 pathways in TGF-β signaling. J. Biol. Chem. 274, 8949-8957 (1999).
  57. Dai P, Akimaru H, Tanaka Y, Maekawa T, Nakafuku M & Ishii S: Sonic hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274, 8143-8152 (1999).
  58. Tokitou F, Nomura T, Khan MM, Kaul SC, Wadhwa R, Yasukawa T, Kohno I & Ishii S: Viral-Ski inhibits retinoblastoma protein (Rb)-mediated transcriptional repression in a dominant negative fashion. J. Biol. Chem. 274, 4485-4488 (1999).
  59. Tavner FJ, Simpson R, Tashiro S, Favier D, Jenkins NA, Gilbert DJ, Copelend NG, Macmillan EM, Lutwyche J, Keough RA, Ishii S & Gonda TJ: Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in trans-activation by Myb. Mol. Cell. Biol. 18, 989-1002 (1998).
  60. Sano Y, Tokitou F, Dai P, Maekawa T, Yamamoto T & Ishii S: CBP alleviates the intramolecular inhibition of ATF-2 function. J. Biol. Chem. 273, 29098-29105 (1998).
  61. Akimaru H, Chen Y, Dai P, Hou DX, Nonaka M, Smolik SM, Armstromg S, Goodman R & Ishii S: Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signaling. Nature 386, 735-738 (1997).
  62. Kanei-Ishii C*, Tanikawa J*, Nakai A, Morimoto RI & Ishii S (* equally contributed): Activation of heat shock transcription factor 3 by c-Myb in the absence of cellular stress. Science 277, 246-248 (1997).
  63. Akimaru H, Hou DX & Ishii S: Drosophila CBP mutations generate twisted embryo: requirement of CBP for dorsal-dependent twist gene expression. Nature Genetics 17, 211-214 (1997).
  64. Tanaka Y, Naruse I, Maekawa T, Masuya H, Shiroishi T & Ishii S: Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome. Proc. Natl. Acad. Sci. USA. 94, 10215-10220 (1997).
  65. Oda M, Furukawa K, Ogata K, Sarai A, Ishii S, Nishimura Y & Nakamura H: Investigation of the pyrinidine preference by the c-Myb DNA-binding domain at the initial base of the consensus sequence. J. Biol. Chem. 272, 17966-17971 (1997).
  66. Ogata K, Kanei-Ishii C, Sasaki M, Hatanaka H, Nagadoi A, Enari M, Nakamura H, Nishimura Y, Ishii S & Sarai A: The cavity in the hydrophobic core of Myb DNA-binding domain is reserved for DNA recognition and trans-activation. Nature Structural Biology 3, 178-187 (1996). (Cover)
  67. Dai P, Akimaru H, Tanaka Y, Hou DX, Yasukawa T, Kanei-Ishii C, Takahashi T & Ishii S: CBP as a transcriptional coactivator of c-Myb. Genes Dev. 10, 528-540 (1996).
  68. Ogata K, Morikawa S, Nakamura H, Hojo H, Yoshimura S, Zhang R, Aimoto S, Ametani Y, Hirata Z, Sarai A, Ishii S & Nishimura Y.: Solution structures of the c-Myb DNA-binding domain: comparison between the free and DNA-complxed forms. Nature Structural Biology 2, 309-320 (1995).
  69. Mizuguchi G, Kanei-Ishii C, Takahashi T, Yasukawa T, Nagase T, Horikoshi M, Yamamoto T & Ishii S: c-Myb repression of c-erbB-2 transcription by direct binding to the c-erbB-2 promoter. J. Biol. Chem. 270, 9384-9389 (1995).
  70. Yasukawa T, Kanei-Ishii C, Maekawa T, Fujimoto J, Yamamoto T & Ishii S: Increase of solubility of foreign proteins in Escherichia coli by coproduction of the bacterial thioredoxin. J. Biol. Chem. 270, 25328-25331 (1995).
  71. Ogata K, Morikawa S, Nakamura H, Sekikawa A, Inoue T, Kanai H, Sarai A, Ishii S & Nishimura Y: Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices. Cell 79, 639-648 (1994).
  72. Terasawa H, Kohda D, Hatanaka H, Tsuchiya S, Ogura K, Nagata K, Ishii S, Mandiyan V, Ullrich A, Schlessinger J & Inagaki F: Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos. Nature Structural Biology 1, 891-897 (1994).
  73. Kanei-Ishii C, Yasukawa T, Morimoto RI & Ishii S: c-Myb-induced trans-activation mediated by heat shock elements without sequence-specific DNA binding of c-Myb. J. Biol. Chem. 269, 15768-15775 (1994).
  74. Tanikawa J, Yasukawa T, Enari M, Ogata K, Nishimura Y, Ishii S & Sarai A.: Recognition of specific DNA sequences by the c-myb proto-oncogene product: role of three repeat units in the DNA-binding domain. Proc. Natl. Acad. Sci. USA 90, 9320-9324 (1993).
  75. Nomura T, Sakai N, Sarai A, Sudo T, Kanei-Ishii C, Ramsay RG, Favier D, Gonda TJ & Ishii, S: Negative autoregulation of c-Myb activity by homodimer formation through the leucine zipper. J. Biol. Chem. 268, 21914-21923 (1993).
  76. Nakagoshi H, Takemoto Y & Ishii S: Functional domains of the human B-myb gene product. J. Biol. Chem. 268, 14161-14167 (1993).
  77. Nagase T, Nomura N & Ishii S: Complex formation between proteins encoded by the ski gene family. J. Biol. Chem. 268, 13710-13716 (1993).
  78. Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T & Ishii S: Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1. J. Biol. Chem. 268, 4259-4266 (1993).
  79. Ogata K, Hojo H, Aimoto S, Nakai T, Nakamura H, Sarai A, Ishii S & Nishimura Y: Solution structure of a DNA-binding unit of Myb: a helix-turn-helix-related motif with conserved tryptophans forming a hydrophobic core. Proc. Natl. Acad. Sci. USA 89, 6428-6432 (1992).
  80. Aoyama N, Nagase T, Sawazaki T, Mizuguchi G, Fujisawa J, Yoshida M & Ishii S: Overlap of the p53 responsive element and cyclic AMP responsive element in the enhancer of human T-cell leukemia virus-I. Proc. Natl. Acad. Sci. USA 89, 5403-5407 (1992).
  81. Kanei-Ishii C, Macmillan EM, Nomura T, Sarai A, Ramsay RG, Aimoto S, Ishii S & Gonda TJ: trans-Aactivation and transformation by Myb are negatively regulated by a leucine zipper structure. Proc. Natl. Acad. Sci. USA 89, 3088-3092 (1992).
  82. Inagaki N, Maekawa T, Sudo T, Ishii S, Seino Y & Imura H: c-Jun represses the human insulin promoter activity that depends on multiple cyclic AMP response elements. Proc. Natl. Acad. Sci. USA 89, 1045-1049 (1992).
  83. Zu YL, Takamatsu Y, Zhao M-J, Maekawa T, Handa H & Ishii S.: Transcriptional regulation by a point mutant of adenovirus-2 E1a product lacking DNA binding activity. J. Biol. Chem. 267, 20181-20187 (1992).
  84. Ramsay RG, Ishii S & Gonda TJ: Interaction of the Myb protein with specific DNA binding sites. J. Biol. Chem. 267, 5656-5662 (1992).
  85. Zu YL, Maekawa T, Matsuda S & Ishii S: Complete putative metal finger and leucine zipper structures of CRE-BP1 are required for the E1A-induced trans-activation. J. Biol. Chem. 266, 24134-24139 (1991).
  86. Matsuda S, Maekawa T & Ishii S: Identification of the functional domains of the transcriptional regulator CRE-BP1. J. Biol. Chem. 266, 18188-18193 (1991).
  87. Nomura N, Zhao MJ, Nagase T, Maekawa T, Ishizaki R, Tabata S & Ishii S: HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer binding protein. J. Biol. Chem. 266, 8590-8594 (1991).
  88. Kanei-Ishii C, Sarai A, Sawazaki T, Nakagoshi H, He DN, Ogata K, Nishimura Y & Ishii S: The tryptophan cluster: a hypothetical structure of the DNA-binding domain of the myb proto-oncogene product. J. Biol. Chem. 265, 19990-19995 (1990).
  89. Nagase T, Sudo T, Maekawa T, Yoshimura T, Fujisawa J, Yoshida M & Ishii S: Promoter region of the human CRE-BP1 gene encoding the transcriptional regulator binding to the cyclic AMP response element. J. Biol. Chem. 265, 17300-17306 (1990).
  90. Mizuguchi G, Nakagoshi H, Nagase T, Nomura N, Date T, Ueno Y & Ishii S: DNA binding activity and transcriptional activator function of the human B-myb protein compared with c-MYB. J. Biol. Chem. 265, 9280-9284 (1990).
  91. Nakagoshi H, Nagase T, Kanei-Ishii C, Ueno Y & Ishii S: Binding of the c-myb proto-oncogene product to the simian virus 40 enhancer stimulates transcription. J. Biol. Chem. 265, 3479-3483 (1990).
  92. Maekawa T, Sakura H, Kanei-Ishii C, Sudo T, Yoshimura T, Fujisawa J, Yoshida M & Ishii S: Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. EMBO J. 8, 2023-2028 (1989).
  93. Sakura H, Kanei-Ishii C, Nagase T, Nakagoshi H, Gonda TJ & Ishii S: Delineation of the three functional domains of the transcriptional activator encoded by the c-myb protooncogene. Proc. Natl. Acad. Sci. USA 86, 5758-5762 (1989).
  94. Maekawa T, Sakura H, Sudo T & Ishii S: Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1. J. Biol. Chem. 264, 14591-14593 (1989).
  95. Maekawa T, Imamoto F, Merlino GT, Pastan I & Ishii S: Cooperative function of two separate enhancers of the human epidermal growth factor receptor proto-oncogene. J. Biol. Chem. 264, 5488-5494 (1989).
  96. Maekawa T, Itoh F, Okamoto T, Kurimoto M, Imamoto F & Ishii S: Identification and purification of the enhancer-binding factor of human immunodeficiency virus-1. J. Biol. Chem. 264, 2826-2831 (1989)

研究室発足以前の主要発表原著論文

  1. Ishii S, Imamoto F, Yamanashi Y, Toyoshima K & Yamamoto T.: Characterization of the promoter region of the human c-erbB-2 protooncogene. Proc. Natl. Acad. Sci. USA 84, 4374-4378 (1987).
  2. Ishii S, Kadonaga JT, Tjian R, Brady JN, Merlino GT & Pastan I: Binding of the Sp1 transcription factor by the human Harvey ras 1 proto-oncogene promoter. Science 232, 1410-1413 (1986).
  3. Ishii S, Merlino GT & Pastan I: Promoter region of the human Harvey ras protooncogene: similarity to the EGF receptor protooncogene promoter. Science 230, 1378-1381 (1985).
  4. Ishii S, Xu Y-H, Stratton RH, Roe BA, Merlino GT & Pastan I: Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene Proc. Natl. Acad. Sci. USA
    82, 4920-4924 (1985).
  5. Clark AJL, Ishii S, Richert N, Merlino GT & Pastan I: Epidermal growth factor regulates the expression of its own receptor. Proc. Natl. Acad. Sci. USA 82, 8327-8378 (1985).
  6. Xu YH, Ishii S, Clark AJL, Sullivan M, Wilson RK, Ma DP, Roe BA, Merlino GT & Pastan I: Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells. Nature 309, 806-810 (1984).
  7. Merlino GT, Xu YH, Ishii S, Clark AJL, Semba K, Toyoshima K, Yamamoto T & Pastan I: Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science 224, 417-419 (1984).
  8. Ishii S, Kuroki K & Imamoto F: tRNAMet gene in the leader region of the nusA operon in Escherichia coli. Proc. Natl. Acad. Sci. USA 81, 409-413 (1984).