研究室発足以後の主要発表原著論文
  (最近の論文については、 PubMedにリンクしています。)

  1. Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Chatton B, Inoue K, Uchiyama T, Ishibashi K, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M & Ishii S: The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory. Nat. Immunol. 16, 1034-1043 (2015).

  2. Shinagawa T, Huynh ML, Takagi T, Tsukamoto D, Tomaru C, Kwak HG, Dohmae N, Noguchi J & Ishii S: Disruption of Th2a and Th2b genes causes defects in spermatogenesis. Development 142, 1287-1292 (2015).

  3. Shinagawa T, Takagi T, Tsukamoto D, Tomaru C, Huynh LM, Sivaraman P, Kumarevel T, Inoue K, Nakato R, Katou Y, Sado T, Takahashi S, Ogura A, Shirahige K & Ishii S: Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells. Cell Stem Cell 14, 217-227 (2014).

  4. Zaman MM, Nomura T, Takagi T, Okamura T, Jin W, Shinagawa T, Tanaka Y & Ishii S: Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates TNF-α-induced apoptosis. Mol. Cell. Biol. 33, 4971-4984 (2013).

  5. Seong KH, Li D, Shimizu H, Nakamura R & Ishii S: Inheritance of stress-induced, ATF-2-dependent epigenetic change. Cell 145, 1049-1061 (2011).
  6. Staton TL, Lazarevic V, Jones DC, Lanser AJ, Takagi T, Ishii S & Glimcher LH: Dampening of death pathways by Schnurri-2 is essential for T cell development. Nature 472, 105-109 (2011).
  7. Jones DC, Schweitzer MN, Wein M, Sigrist K, Takagi T, Ishii S & Glimcher LH: Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3. Proc. Natl. Acad. Sci. USA. 107, 8254-8258 (2010).

  8. Maekawa T*, Kim S*, Nakai D, Makino C, Takagi T, Ogura H, Yamada K, Chatton B & Ishii S (*equally contributed): Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene. EMBO J. 29, 196-208 (2010).
  9. Maekawa T, Jin W & Ishii S: The role of ATF-2 family transcription factors in adipocyte differentiation: anti-obesity effects of p38 inhibitors. Mol. Cell. Biol. 30, 613-625 (2010).
  10. Yamauchi T, Ishidao T, Nomura T, Shinagawa T, Tanaka Y, Yonemura S & Ishii S: A B-Myb complex containing clathrin and filamin is required for mitotic spindle function. EMBO J. 27, 1852-1862 (2008).
  11. Shimizu H, Shimoda M, Yamaguchi T, Seong KH & Ishii S: Drosophila ATF-2 regulates sleep and locomotor activity in pacemaker neurons. Mol. Cell. Biol. 28, 6278-6289 (2008).
  12. Kanei-Ishii C, Nomura T, Takagi T, Watanabe N, Nakayama KI & Ishii S: Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation. J. Biol. Chem. 283, 30540-30548 (2008).
  13. Maekawa T, Shinagawa T, Sano Y, Sakuma T, Nomura S, Nagasaki K, Miki Y, Saito-Ohara F, Inazawa J, Kohno T, Yokota J & Ishii S: Reduced levels of ATF-2 predispose mice to mammary tumors. Mol. Cell. Biol 27, 1730-1744 (2007).
  14. Okamura T, Shimizu H, Nagao T, Ueda R & Ishii S: ATF-2 regulates fat metabolism in Drosophila. Mol. Biol. Cell 18, 1519-1529 (2007).
  15. Kajino T, Omori E, Ishii S, Matsumoto K & Ninomiya-Tsuji J : TAK1 MAPKKK mediates TGF-β signaling by targeting SnoN oncoprotein for degradation. J. Biol. Chem 282, 9475-9481 (2007).
  16. Saita Y, Takagi T, Kitahara K, Usui M, Ezura Y, Nakashima K, Kurosawa H, Ishii S & Noda M: Lack of Schnurri-2 expression associates with reduced bone remodeling and osteopenia. J. Biol. Chem 282, 12907-12915 (2007) .
  17. Zhou H, Kim S, Ishii S & Boyer TG: Mediator modulates Gli3-dependent Sonic hedgehog signaling. Mol. Cell. Biol 26, 8667-8682 (2006).
  18. Jin W, Takagi T, Kanesashi S, Kurahashi T, Nomura T, Harada J & Ishii S: Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins. Dev. Cell 10, 461-471 (2006). (Selected as a featured article)
  19. Morita Y, Kanei-Ishii C, Nomura T & Ishii S: TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation. Mol. Biol. Cell 16, 5433-5444 (2005).
  20. Kurahashi T, Nomura T, Kanei-Ishii C, Shinkai Y & Ishii S: The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. Mol. Biol. Cell 16, 4705-4713 (2005).
  21. Sano Y, Akimaru H, Okamura T, Nagao T, Okada M & Ishii S: Drosophila activating transcription factor-2 is involved in stress response via activation by p38, but not c-Jun NH(2)-terminal kinase. Mol. Biol. Cell 16, 2934-2946 (2005).
  22. Kimura MY, Hosokawa H, Yamashita M, Hasegawa A, Iwamura C, Watarai H, Taniguchi M, Takagi T, Ishii S & Nakayama T: Regulation of T helper type 2 cell differentiation by murine Schnurri-2. J. Exp. Med. 201, 397-408 (2005).
  23. Tanikawa J, Nomura T, Macmillan EM, Shinagawa T, Jin W, Kokura K, Baba D, Shirakawa M, Gonda TJ & Ishii S: p53 suppresses c-Myb-induced trans-activation and transformation by recruiting the corepressor mSin3A. J. Biol. Chem. 279, 55393-55400 (2004).
  24. Kanei-Ishii C, Nomura T, Tanikawa J, Ichikawa-Iwata E & Ishii S: Differential sensitivity of v-Myb and c-Myb to Wnt-1-induced protein degradation. J. Biol. Chem. 279, 44582-44589 (2004).
  25. Kanei-Ishii C, Ninomiya-Tsuji J, Tanikawa J, Nomura T, Ishitani T, Kishida S, Kokura K, Kurahashi T, Ichikawa-Iwata E, Kim Y, Matsumoto K & Ishii S: Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 18, 816-829 (2004).
  26. Nomura T, Tanikawa J, Akimaru H, Kanei-Ishii C, Ichikawa-Iwata E, Khan MM, Ito H & Ishii S: Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1β and Ski. J. Biol. Chem. 279, 16715-16726 (2004).
  27. Alarcon JM, Malleret G, Touzani K, Vronskaya S, Ishii S, Kandel ER & Barco A.: Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice; a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron 42, 947-959 (2004). (Cover)
  28. Khan MM, Nomura T, Chiba T, Tanaka K, Yoshida H, Mori K & Ishii S: The fusion oncoprotein PML-RARαinduces endoplasmic reticulum-associated degradation of N-CoR and ER stress. J. Biol. Chem. 279, 11814-11824 (2004).
  29. Dai P*, Akimaru H* & Ishii S: (*equally contributed): A Hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of Ci. Dev. Cell 4, 917-928 (2003). (Selected as a featured article)
  30. Shinagawa T & Ishii S: Generation of Ski-knock down mice by expressing a long double-strand RNA from an RNA polynerase II promoter. Genes Dev. 17, 1340-1345 (2003).
  31. Harada J, Kanei-Ishii C, Nomura T, Khan MM, Kim Y & Ishii S: Requirement of the co-repressor HIPK2 for Ski-mediated inhibition of BMP-induced transcriptional activation. J. Biol. Chem. 278, 38998-9005 (2003).
  32. Kokura K, Nomura T, Khan MM, Kim H & Ishii S: The Ski-binding protein C184M negatively regulate TGF-βsignaling by sequestering the Smad proteins to cytoplasm. J. Biol. Chem. 278, 20133-20139 (2003).
  33. Chen D, Xu W, Bales E, Colmenares C, Conacci-Sorrell M, Ishii S, Stavnezer E, Campisi J, Fisher DE, Ben-Ze'ev A & Medrano EE: SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res. 63, 6626-6634 (2003).
  34. Dai P*, Shinagawa T*, Nomura T, Harada J, Kaul SC, Wadhwa R, Akimaru H, Sasaki H, Colmenares C & Ishii S (*equally contributed): Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev. 16, 2843-2848 (2002).
  35. Okada M*, Akimaru H*, Hou D-X, Takahashi T & Ishii S (* equally contributed): Myb controls G2/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc. EMBO J. 21,675-684 (2002).
  36. Tahirov TH, Sato K, Ichikawa-Iwata E, Sasaki M, Inoue-Bungo T, Shiina M, Kimura K, Takata S, Fujikawa A, Morii H, Kumasaka T, Yamamoto M, Ishii S & Ogata K: Mechanism of c-Myb-C/EBPβcooperation from separated sites on a promoter. Cell 108, 57-70 (2002). (Cover)
  37. Takagi T, Harada J & Ishii S: Murine Schnurri-2 is required for positive selection of thymocytes. Nature Immunol. 2, 1048-1053 (2001).(described in News & Views)
  38. Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP & Ishii S: Role of PML and PML-RARα in Mad-mediated transcriptional repression. Mol. Cell 7, 1233-1243 (2001). (Cover)
  39. Tahirov TH, Inoue T, Sasaki M, Kimura K, Morii H, Fujikawa A, Shiina M, Sato K, Kumasaka T, Yamamoto M, Ishii S & Ogata K: Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFβ. Cell 104, 755-767 (2001).
  40. Harbers M, Nomura T, Ohno S & Ishii S: Intracellular localization of the Ret finger protein depends on a functional nuclear export signal and protein kinase C activation. J. Biol. Chem. 276, 48596-48607 (2001).
  41. Khan MM, Nomura T, Kim H, Kaul CS, Wadhwa R, Zhong S, Pandolfi PP & Ishii S: PML-RARα alleviates the transcriptinal repression mediated by tumor suppressor Rb. J. Biol. Chem. 276, 43491-43494 (2001).
  42. Kokura K, Kaul SC, Wadhwa R, Nomura T, Khan MM, Shinagawa T, Yasukawa T, Colmenares C & Ishii S: The Ski protein family is reqired for MeCP2-mediated transcriptional repression. J. Biol. Chem. 276, 34115-34121 (2001).
  43. Sano Y & Ishii S: Increased affinity of c-Myb for CBP after CBP-induced acetylation. J. Biol. Chem. 276, 3674-3682 (2001).
  44. Monzen K, Hiroi Y, Kudoh S, Akazawa H, Oka T, Takimoto E, Hayashi D, Hosoda T, Kawabata M, Miyazono K, Ishii S, Yazaki Y, Nagai R & Komuro I: Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation. J. Cell Biol. 153, 687-698 (2001).
  45. Shinagawa T, Dong HD, Xu M, Maekawa T & Ishii S: The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice. EMBO J. 19, 2280-2291 (2000).
  46. Tanikawa J, Ichikawa-Iwata E, Kanei-Ishii C, Nakai A, Matsuzawa S, Reed JC & Ishii S: p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3. J. Biol. Chem. 275, 15578-15585 (2000).
  47. Nomura T, Khan MM, Kaul SC, Dong HD, Wadhwa R, Colmenare C, Khono I & Ishii S: Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes Dev. 13, 412-423 (1999).
  48. Tanaka Y, Patestos NP, Maekawa T & Ishii S: B-myb is required for inner cell mass formation at an early stage of development. J. Biol. Chem. 274, 28067-28070 (1999).
  49. Maekawa T, Bernier F, Sato M, Nomura S, Singh M, Inoue Y, Tokunaga T, Imai H, Yokoyama M, Reimold A, Glimcher LH & Ishii S: Mouse ATF-2 null mutants display features of severe type of meconium aspiration syndrome. J. Biol. Chem. 274,17813-17819 (1999).
  50. Sano Y, Harada J, Tashiro S, Gotoh-Mandeville R, Maekawa T & Ishii S: ATF-2 is a common nuclear target of Smad and TAK1 pathways in TGF-β signaling. J. Biol. Chem. 274, 8949-8957 (1999).
  51. Dai P, Akimaru H, Tanaka Y, Maekawa T, Nakafuku M & Ishii S: Sonic hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J. Biol. Chem. 274, 8143-8152 (1999).
  52. Tokitou F, Nomura T, Khan MM, Kaul SC, Wadhwa R, Yasukawa T, Kohno I & Ishii S: Viral-Ski inhibits retinoblastoma protein (Rb)-mediated transcriptional repression in a dominant negative fashion. J. Biol. Chem. 274, 4485-4488 (1999).
  53. Tavner FJ, Simpson R, Tashiro S, Favier D, Jenkins NA, Gilbert DJ, Copelend NG, Macmillan EM, Lutwyche J, Keough RA, Ishii S & Gonda TJ: Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in trans-activation by Myb. Mol. Cell. Biol. 18, 989-1002 (1998).
  54. Sano Y, Tokitou F, Dai P, Maekawa T, Yamamoto T & Ishii S: CBP alleviates the intramolecular inhibition of ATF-2 function. J. Biol. Chem. 273, 29098-29105 (1998).
  55. Akimaru H, Chen Y, Dai P, Hou DX, Nonaka M, Smolik SM, Armstromg S, Goodman R & Ishii S: Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signaling. Nature 386, 735-738 (1997).
  56. Kanei-Ishii C*, Tanikawa J*, Nakai A, Morimoto RI & Ishii S (* equally contributed): Activation of heat shock transcription factor 3 by c-Myb in the absence of cellular stress. Science 277, 246-248 (1997).
  57. Akimaru H, Hou DX & Ishii S: Drosophila CBP mutations generate twisted embryo: requirement of CBP for dorsal-dependent twist gene expression. Nature Genetics 17, 211-214 (1997).
  58. Tanaka Y, Naruse I, Maekawa T, Masuya H, Shiroishi T & Ishii S: Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome. Proc. Natl. Acad. Sci. USA. 94, 10215-10220 (1997).
  59. Oda M, Furukawa K, Ogata K, Sarai A, Ishii S, Nishimura Y & Nakamura H: Investigation of the pyrinidine preference by the c-Myb DNA-binding domain at the initial base of the consensus sequence. J. Biol. Chem. 272, 17966-17971 (1997).
  60. Ogata K, Kanei-Ishii C, Sasaki M, Hatanaka H, Nagadoi A, Enari M, Nakamura H, Nishimura Y, Ishii S & Sarai A: The cavity in the hydrophobic core of Myb DNA-binding domain is reserved for DNA recognition and trans-activation. Nature Structural Biology 3, 178-187 (1996). (Cover)
  61. Dai P, Akimaru H, Tanaka Y, Hou DX, Yasukawa T, Kanei-Ishii C, Takahashi T & Ishii S: CBP as a transcriptional coactivator of c-Myb. Genes Dev. 10, 528-540 (1996).
  62. Ogata K, Morikawa S, Nakamura H, Hojo H, Yoshimura S, Zhang R, Aimoto S, Ametani Y, Hirata Z, Sarai A, Ishii S & Nishimura Y.: Solution structures of the c-Myb DNA-binding domain: comparison between the free and DNA-complxed forms. Nature Structural Biology 2, 309-320 (1995).
  63. Mizuguchi G, Kanei-Ishii C, Takahashi T, Yasukawa T, Nagase T, Horikoshi M, Yamamoto T & Ishii S: c-Myb repression of c-erbB-2 transcription by direct binding to the c-erbB-2 promoter. J. Biol. Chem. 270, 9384-9389 (1995).
  64. Yasukawa T, Kanei-Ishii C, Maekawa T, Fujimoto J, Yamamoto T & Ishii S: Increase of solubility of foreign proteins in Escherichia coli by coproduction of the bacterial thioredoxin. J. Biol. Chem. 270, 25328-25331 (1995).
  65. Ogata K, Morikawa S, Nakamura H, Sekikawa A, Inoue T, Kanai H, Sarai A, Ishii S & Nishimura Y: Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices. Cell 79, 639-648 (1994).
  66. Terasawa H, Kohda D, Hatanaka H, Tsuchiya S, Ogura K, Nagata K, Ishii S, Mandiyan V, Ullrich A, Schlessinger J & Inagaki F: Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos. Nature Structural Biology 1, 891-897 (1994).
  67. Kanei-Ishii C, Yasukawa T, Morimoto RI & Ishii S: c-Myb-induced trans-activation mediated by heat shock elements without sequence-specific DNA binding of c-Myb. J. Biol. Chem. 269, 15768-15775 (1994).
  68. Tanikawa J, Yasukawa T, Enari M, Ogata K, Nishimura Y, Ishii S & Sarai A.: Recognition of specific DNA sequences by the c-myb proto-oncogene product: role of three repeat units in the DNA-binding domain. Proc. Natl. Acad. Sci. USA 90, 9320-9324 (1993).
  69. Nomura T, Sakai N, Sarai A, Sudo T, Kanei-Ishii C, Ramsay RG, Favier D, Gonda TJ & Ishii, S: Negative autoregulation of c-Myb activity by homodimer formation through the leucine zipper. J. Biol. Chem. 268, 21914-21923 (1993).
  70. Nakagoshi H, Takemoto Y & Ishii S: Functional domains of the human B-myb gene product. J. Biol. Chem. 268, 14161-14167 (1993).
  71. Nagase T, Nomura N & Ishii S: Complex formation between proteins encoded by the ski gene family. J. Biol. Chem. 268, 13710-13716 (1993).
  72. Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T & Ishii S: Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1. J. Biol. Chem. 268, 4259-4266 (1993).
  73. Ogata K, Hojo H, Aimoto S, Nakai T, Nakamura H, Sarai A, Ishii S & Nishimura Y: Solution structure of a DNA-binding unit of Myb: a helix-turn-helix-related motif with conserved tryptophans forming a hydrophobic core. Proc. Natl. Acad. Sci. USA 89, 6428-6432 (1992).
  74. Aoyama N, Nagase T, Sawazaki T, Mizuguchi G, Fujisawa J, Yoshida M & Ishii S: Overlap of the p53 responsive element and cyclic AMP responsive element in the enhancer of human T-cell leukemia virus-I. Proc. Natl. Acad. Sci. USA 89, 5403-5407 (1992).
  75. Kanei-Ishii C, Macmillan EM, Nomura T, Sarai A, Ramsay RG, Aimoto S, Ishii S & Gonda TJ: trans-Aactivation and transformation by Myb are negatively regulated by a leucine zipper structure. Proc. Natl. Acad. Sci. USA 89, 3088-3092 (1992).
  76. Inagaki N, Maekawa T, Sudo T, Ishii S, Seino Y & Imura H: c-Jun represses the human insulin promoter activity that depends on multiple cyclic AMP response elements. Proc. Natl. Acad. Sci. USA 89, 1045-1049 (1992).
  77. Zu YL, Takamatsu Y, Zhao M-J, Maekawa T, Handa H & Ishii S.: Transcriptional regulation by a point mutant of adenovirus-2 E1a product lacking DNA binding activity. J. Biol. Chem. 267, 20181-20187 (1992).
  78. Ramsay RG, Ishii S & Gonda TJ: Interaction of the Myb protein with specific DNA binding sites. J. Biol. Chem. 267, 5656-5662 (1992).
  79. Zu YL, Maekawa T, Matsuda S & Ishii S: Complete putative metal finger and leucine zipper structures of CRE-BP1 are required for the E1A-induced trans-activation. J. Biol. Chem. 266, 24134-24139 (1991).
  80. Matsuda S, Maekawa T & Ishii S: Identification of the functional domains of the transcriptional regulator CRE-BP1. J. Biol. Chem. 266, 18188-18193 (1991).
  81. Nomura N, Zhao MJ, Nagase T, Maekawa T, Ishizaki R, Tabata S & Ishii S: HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer binding protein. J. Biol. Chem. 266, 8590-8594 (1991).
  82. Kanei-Ishii C, Sarai A, Sawazaki T, Nakagoshi H, He DN, Ogata K, Nishimura Y & Ishii S: The tryptophan cluster: a hypothetical structure of the DNA-binding domain of the myb proto-oncogene product. J. Biol. Chem. 265, 19990-19995 (1990).
  83. Nagase T, Sudo T, Maekawa T, Yoshimura T, Fujisawa J, Yoshida M & Ishii S: Promoter region of the human CRE-BP1 gene encoding the transcriptional regulator binding to the cyclic AMP response element. J. Biol. Chem. 265, 17300-17306 (1990).
  84. Mizuguchi G, Nakagoshi H, Nagase T, Nomura N, Date T, Ueno Y & Ishii S: DNA binding activity and transcriptional activator function of the human B-myb protein compared with c-MYB. J. Biol. Chem. 265, 9280-9284 (1990).
  85. Nakagoshi H, Nagase T, Kanei-Ishii C, Ueno Y & Ishii S: Binding of the c-myb proto-oncogene product to the simian virus 40 enhancer stimulates transcription. J. Biol. Chem. 265, 3479-3483 (1990).
  86. Maekawa T, Sakura H, Kanei-Ishii C, Sudo T, Yoshimura T, Fujisawa J, Yoshida M & Ishii S: Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. EMBO J. 8, 2023-2028 (1989).
  87. Sakura H, Kanei-Ishii C, Nagase T, Nakagoshi H, Gonda TJ & Ishii S: Delineation of the three functional domains of the transcriptional activator encoded by the c-myb protooncogene. Proc. Natl. Acad. Sci. USA 86, 5758-5762 (1989).
  88. Maekawa T, Sakura H, Sudo T & Ishii S: Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1. J. Biol. Chem. 264, 14591-14593 (1989).
  89. Maekawa T, Imamoto F, Merlino GT, Pastan I & Ishii S: Cooperative function of two separate enhancers of the human epidermal growth factor receptor proto-oncogene. J. Biol. Chem. 264, 5488-5494 (1989).
  90. Maekawa T, Itoh F, Okamoto T, Kurimoto M, Imamoto F & Ishii S: Identification and purification of the enhancer-binding factor of human immunodeficiency virus-1. J. Biol. Chem. 264, 2826-2831 (1989)

研究室発足以前の主要発表原著論文

  1. Ishii S, Imamoto F, Yamanashi Y, Toyoshima K & Yamamoto T.: Characterization of the promoter region of the human c-erbB-2 protooncogene. Proc. Natl. Acad. Sci. USA 84, 4374-4378 (1987).
  2. Ishii S, Kadonaga JT, Tjian R, Brady JN, Merlino GT & Pastan I: Binding of the Sp1 transcription factor by the human Harvey ras 1 proto-oncogene promoter. Science 232, 1410-1413 (1986).
  3. Ishii S, Merlino GT & Pastan I: Promoter region of the human Harvey ras protooncogene: similarity to the EGF receptor protooncogene promoter. Science 230, 1378-1381 (1985).
  4. Ishii S, Xu Y-H, Stratton RH, Roe BA, Merlino GT & Pastan I: Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene Proc. Natl. Acad. Sci. USA
    82, 4920-4924 (1985).
  5. Clark AJL, Ishii S, Richert N, Merlino GT & Pastan I: Epidermal growth factor regulates the expression of its own receptor. Proc. Natl. Acad. Sci. USA 82, 8327-8378 (1985).
  6. Xu YH, Ishii S, Clark AJL, Sullivan M, Wilson RK, Ma DP, Roe BA, Merlino GT & Pastan I: Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells. Nature 309, 806-810 (1984).
  7. Merlino GT, Xu YH, Ishii S, Clark AJL, Semba K, Toyoshima K, Yamamoto T & Pastan I: Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science 224, 417-419 (1984).
  8. Ishii S, Kuroki K & Imamoto F: tRNAMet gene in the leader region of the nusA operon in Escherichia coli. Proc. Natl. Acad. Sci. USA 81, 409-413 (1984).